There are actually 2 options on doing it that are fairly useful, but for both i used 2 amplifiers, in both slots.
One (my first 3 star) was achived by not using missiles at all. There arent any fast or agile enemies, as such plasma cannon (last weapon) when fully upgraded dominates missiles due to it's powerful single target.
Second one uses the puny ice cannon. while cannon itself does almost no damage, it still aplies debuff.
Hope it helps.
