Well, it depends on the classes you are playing.I have only finished game with mage and rogue and currently playing with warrior.
With rogue survivor and master survivor- skills are really good regardless your weapons.They gain you great hp and stamina regeneration.With archer-style concentration and all passive buffs seem to be good, because Alyss have them (I havent tryed archer style myself).With assasin-style flip kick and cripple are good imo.Flip kick allows you to stun an enemy and cripple prevents one enemy`s damage except touch of death -attack ingores it.Also gut and blade fury skills are good for dealing damage and combining them with precision- skill adds more damage (because your attacks deal critical more often).Cutthroat seemed useless to me: it doesn`t do that much damage and get resisted often when enemies are elite or better which happens often at late game.
For wizard conductive shock and lightning felt good, because they ignore armor.Boulder felt useless, it doesnt do more damage than your basic attack at mid game!But I played with necro style, so most of my skills were summoning ones.