Family Guy is strongly based on "OMG its so random its funneh" comedy, which is something I can't stand. There are a few moments that are referentially funny (like spoofing famous people), but otherwise I find it annoying. I don't mind the sexual innuendos though - when I want something like that I go to Family Guy.
I used to absolutely love Futurama, but I own every season and have seen every episode at least a dozen times, so I'm a little burnt out on the series. It used to be the only reason I'd watch TV.
The Simpsons contains so many hidden political messages it isn't funny anymore. The episodes were great up until around 2004/2005. After that Matt Groening went crazy with the show.
Beavis and Butt-Head is one of those I'll watch for a few hours to kill an afternoon. If I watch it too often I'll get tired of it because it's so repetitive. I have season one that I bought a year ago, but I've only watched the first two discs so far.
South Park is too outlandish for me. My friends watch it and laugh their blanks off but the humor just doesn't click for me. I get the jokes, it's just that I don't find it funny.
Then again, I'm probably just being too particular.
Adventure Time
Check please
I second that motion.