i just was short of beating C5, but the very aggressive flying black made it too hard towards the end. before this i had killed the big grey one (the one which, when he reaches your orb, finishes the game).
the flying black not only sent waves of little black monsters, sometimes he landed on the orb and took a big amount of mana away. i hate this beast.
i then replayed C5, none of both appeared. cleared.
Unless (V1.014) you get 2 spires both on opposite sides, both avoid both your two venom shrine ranges, and only go into them about 3 tiles from your orb. Now, THAT's suspenseful. C: