H is the final orange/black grade 5 gem with cost of grade 6 and huge specials. You can use this formula only once.
METHOD 2 - SUPERGEM UPGRADING
You can apply it to pure orange, pure black, orange/black and orange/black/red gems.
first, get your gem to upgrade (I'll call it "g"
D is the final supergem with grade +3 and cost x16. You can (even should) repeat this method every time when upgrading gem.
You use method 1 once and then on resulting gem method 2 till your mana ends for mana gem. Just don't forget to add red at some point, best g1 to one of 16 copies of your gem in method 2.
For amplifiers I recommend now pure orange (black isn't amped anymore) so you grab g1 and apply method 2. Amplifiers with this method should be 3 grades lower than mana gem.
[EDIT]
After a moment of thinking I realized that this metod works also for killing gems, but you have to farm kills on black/red gem and add it in some moment. Feel free to try.
If sombody wants I can post "method 2" 16x scheme but in more optimal and more complex 32x or 64x version. Recommended for extreme players (beating gem grade records or something) only.
The main confusion though, is in the need to duplicate gems. It would certainly help if gems that needed to be duplicated (or triplicated) were called out.
Still, based on the cost, I got it right ... but it took a couple tries.
psorek and thunder, you cannot be thanked enough for your efforts in furthering the crusade for the vaunted grade 100 gem. Going back to restart for even more ridiculous mana pool size.
