I used to play with arrow keys until I started playing fps on the computer(TF2 FTW). Then the WASD keys just stuck. On games like Exit Path(2D platformers), I use arrow keys
I definetly prefer the arrow keys for games in which i must use the spacebar and other keyboard keys. In a game in which the mouse is a necessity i always use WASD because it is much easier to use my right hand for the mouse. Id be willing to bet Left-handed people would say the exact opposite of me, because i think everyone does what i do, although, i have seen some people using the arrow keys with there left hand :o
It all depends on the game. In my opinion, I like my arrow keys when I have to use the Z,X,C keys and then I use the W,A,S,D keys when I occasionally play Minecraft.