Mine was probably Metal Gear Solid 4.The ENTIRE game is sad.But if i had to choose a specific moment,it would definently be the ending *sniff* it had me in tears.Whats the saddest moment you've seen in a game?Whats the saddest game you've played?

i think for me it was the end of kingdom hearts days.

SPOILERS!!!
i mean, disapearing is one thing but forgeting the person ever existed? that really got me

for me it was when grayfox in msg1 is dying and makes that wonderful speech whilst he is being crushed by liquid, so epic.

Hmmm...there's definitely a few I can think of here. Er, spoiler for about all of 'em.

Towards the ending of Halo 3, where both Miranda Keyes and Sgt. Johnson die...

I agree with thebluerabbit

End of Jack 3, where Jack finds out Damas was his father right before he dies.

Uh, I thought the end of Halo: Reach was also rather depressing.

The ending of Left for Dead felt real to me (since I get into games). I thought I would cry, until I remembered that it was a game.

*SPOILER ALERT*

The saddest moment for me would have to be in Gears of War 3 when I found out that CARMINE DIDN'T DIE!!! :(((((((

The most sad moment in the game is when:

1). Accident myself while enemy at my base.
2). Kill my own teammate.
3). Got disconnect when I almost win the game and the game kick me out say. Lol you surrender.

When John Marston died. I actually choked up.

Splinter Cell Conviction:

OMG that ending was so sad I literally started crying! I hardly remember it because i haven't played the game in a while, but I remember it was sad as HECK!!!

Mortal Kombat:

WHY!!!!?????? EVERYBODY BUT AN OLD HAIRY ASAIN!!!!! WHY!!!!?????? plus some hot chicks died...

Portal 2:

Not all that much sad, but maybe emotional in EVERY way. Maybe not to you but i really got to me.

*it really got to me

When Mctavish dies in MW3