StarCraft II, definitely. I've always been a big RTS junkie. It's not due out for another year though. I'll just have to buckle down and ride out the wait until then.
Super Smash Brawl (Wii) Mario Kart Wii (Wii) Alan Wake (Xbox 360) Battlefield: Bad Company (Xbox 360) GTA IV (Xbox 360) Prototype (Xbox 360) Farcry 2 (Xbox 360) Yes it will come out for the Xbox and PS3
Starcraft II, I am amazed by what I have seen so far, and they haven't even revealed the Zerg yet. I just hope that Activison doesn't get in the way, cause lets face it, Blizzard knows RTSs more that Activison.