I always liked that one from bioshock. "Aphrodite is walking the halls - shimmering, like a scalpel... 'Steinman, 'she calls, 'Steinman! I have what you're looking for! Just open your eyes!' And when I see her, she cuts me into a thousand beautiful pieces."
There are a lot of good quotes from video games. I might return with the ones I find most profound and meaningful. But first, I'll share my absolute total favorite, bar none.
"I'm impressed, but not surprised." Captain Elanor Varrot.
Legacy of Kain has some great quotes in it. Here is some dialogue taken from Soul Reaver 2
Kain: Thirty years hence, I am presented with a dilemma... let's call it a two-sided coin. If the coin falls one way, I sacrifice myself and thus restore the Pillars... but as the last surviving vampire in Nosgoth, this would mean the annihilation of our species... Moebius made sure of that. If the coin lands on the reverse, I refuse the sacrifice and thus doom the Pillars to an eternity of collapse. Either way, the game is rigged.
Raziel: We agree then that the Pillars are crucial and must be restored.
Kain: Yes, Raziel, that is why we've come full-circle to this place.
Raziel: So after all this, you make my case for me. To end this stalemate, you must die so that new Guardians can be born.
Kain: The Pillars don't belong to them, Raziel... they belong to us.
Raziel: Your arrogance is boundless, Kain.
Kain: There's a third option, a monumental secret hidden in your very presence here. But it's a secret you have to discover for yourself. Unearth your destiny, Raziel. It's all laid out for you here.
Raziel: You said it yourself, Kain... there are only two sides to your coin.
Kain: Apparently so, but suppose you throw a coin enough times... suppose one day, it lands on its edge.
"You know, your team is rather talkative. Though you don't seem to say much. Now's your chance to speak, have any last words? "Yeah... my guns do the talking." BANG
Strike Force Heroes 2, last cutscene. This is my all-time favorite cutscene and quote.