I think that either Resident Evil 5(0r Bio Hazard 5) or Prototype are going to be the best games of 2009. I know for sure they are coming out this year.
Killzone 2 or Resident Evil 5 will be the best because Killzone 2 was already rated a 9.4 by IGN and will certainly be an excellent game. Resident Evil 5 will be good cause it's a Resident Evil game and will sell a lot since Resident Evil 4 was a huge success
I think it depends on what category like for action I think that Resident evil 5 will most likely get action title of the year. Madworld I think will get art design cause of how it looks like a comic book when you play it. I think this is a bit pointless cause there are going to be a lot of new games this year and we can't even come close to guessing on what will win cause all we are doing is thinking of games we now are going to come out and picking the best one.