Well let's see. I like a lot of them. Some anime, some comedies. Favorite comedies are clerks, family guy and king of the hill.
Clerks because I loved the movies and they toned the stuff in it down in the cartoon. Family Guy because it's a classic show that makes fun of everything and keeps you laughing. King of the Hill because of its more mild humor and rustic(not sure if it's the word I'm shooting for) feel.
Anime would be Bleach and Full Metal Alchemist. Of the two American versions aired on adult swim, FMA is better, but looking at the later episodes, bleach is better. I like them both because of their great storyline and fighting.
Anime: FMA and Death Note. I like bleach too, but i don't really like the American version very much.
Comedies: Robot Chicken, Superjail, metalocolypse (which I probably spelled wrong, and if its considered a comedy), clerks, ATHF. I find them all hilarious.