Just click new game, then choose relaxed or Realistic, choose your type of germ, then after putting the name, a thing that says tutorial will appear. Just click the x at the top right, and you're free to play.
I started on Japan and got the whole world infected except for like 800,000,000 people. So I couldn't kill off everybody because the vaccine prevented my disease from doing so.
I find that having no symptoms till you get full environmental resistance and Airborne/Waterborne. Then, when you start pumping out symptoms, you get nice death counts.
the way i figure it, you need to stay as low key as possible until your virus gets spread. Once you piss off the media one or two of the Island areas *cough cough Madagasgar* will shut down its ports/Airports/borders and its Good game.
Pretty much in the beggining of the game you dont need to worry about getting any kills. If you can get all of the Areas infected at least a little then you cna start pumping out lethal symptoms.
As opposed to common believes you need to quickly jack up the visibility of the virus as soon as the starting location reach 0.5% infected, therefore slowing down the spread.
Just remember to max the drug thing when the vaccine warning pops up. Thats what i did, and then they couldnt make a vaccine !
I had my Environmental/Drug Resistances fully maxed. Drug resistance doesn't affect vaccine I don't think cause it only mentions hospitals in the description.
Its pretty hard to shut down hospitals, but the only way you can do that is to max out the drug resistance, well that's the best way anyway, like this:
Max Drug Resistance -> Close Down Hospitals -> Slower vaccine creation, or none at all( Depending on if you close down all of them).
But I am wondering what the other resistances help in.. Mayeb they depend on the countries...
Other resistances make you spread faster in certain evironments, I started in Madagascar and had like...2 infections every 10 seconds, bought 2 heat resistances up to level 3 and that went up to like, 20000 or so every second...really big increase.
I have no idea how after they made a vaccine, I managed to shut down all hospitals with 0 drug resistance as a parasite...