I'm the most curious to see how TES V: Skyrim and Deus Ex: Human Revolution turn out. Some of the other games that interest me are Crysis 2 (released), Shogun 2: TW (released), Brink, The Witcher 2, Portal 2 and Battlefield 3.
Deus Ex: Human Revolution most definitely. The originals were PC legends and one of the most original games of all times. It was also the first real decision making game on the market and it made way for games like Bioshock and Mass Effect to be as great as they are.
It was sad for the delay but they are working out the bugs and I'm excited to see the end results! From the graphics I've already seen from demos and gameplay it looks like it's gonna be a game of epic proportion!
I will have to say that every game that has 3 on it that will mean gears of war, Battlefield, and others as well not only the 3 portal MK and much more.