Unless I need to use my right hand for something else, I use the four isolated keys with arrows printed on them for almost all of my gaming. That is, if I'm given the choice.
i usually choose the arrow keys. if there is a game which needs mouse control i choose the wasd. in ep, when there is a level i have to flow and jump to the left i use the wasd just for that level because my keybourd wont let me press space, left, and up XD