You guys know they even deny about being in the mainstream? listen to Rusty James, it has lyrics that say "Anything but the mainstream". now i do agree they are changing their style of music though i wouldn't go as far as saying they are mainstream. they are kinda like in a halfway between stage. Plus they were just trying a new type of style with iUNO!, iDOS!, And iTRE'! Billie Joe even stated that these new albums were just experiments, and they wanted to see how many copies would be sold and if people like this new style. and in the end, if your in a band for like 25 years your style of music WILL change over time. There is no avoiding this.
They are mainstream. There are many punk bands that stayed through to their roots and refused to cave in. GD isn't one of them. Having a song that even decries the band isn't mainstream is the ultimate pathetic signal that the band is mainstream.
Changing your style of music may not be a bad thing. But that doesn't mean they aren't mainstream or sell outs. Lots of punk bands such as GD have sold out, because the very founding principles of punk are rooted in the underground DIY scene, and by making generic, radio friendly music to reach out to more mainstream audiences, they sold out.