I've found Vampire Reaper best for me. With additional +10 str from titles and putting ALL skills into strength - it seems that full growth in strength covers the lack of stamina with vampire health steal on higher levels like 60-70 critical hit is a great healing skill allowing to survive even massive attacks. Equip only highest armor without considering any bonuses. Weapons should be choosed by average damage: weapon with 6-7 (average dmg 6.5) is better than 3-9 (average dmg 6).
fantastic game, no point on playing tho after u reach a certain level . But definitely playing as a vampire helps especially at the when resistance isn`t 100 yet .
Personally chose Golem/Cursed and got to lvl 150/11 mill mana pearls before suiciding out of boredom. Past lvl 25ish, if you have 100+ fire/ice resistance you're fairly invincible, especially if you're target the skeletons/green orbs first. Past level 100 I could just stand in most rooms and be invulnerable because my stamina was so high.
Golem+Cursed because of resistances, it makes getting 100+ fire/ice resistance a lot easier since you start with 40 across the board (Golem+Cursed=highest resistance combination). The random elemental damage also helps late game.
Good point agniz.. Golem cursed and vampire cursed are the best for me since you can get all of the spells from items. But, while golem cursed has high resistances and +1 armor, the benefits pale before the vampire's ability to drain health. And since you can also get high resistances quite easily on higher levels, I think the best choice is vampire cursed.