ForumsWEPRThe Cure for Cancer

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Gstroy
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Gstroy
482 posts
Nomad

  • 18 Replies
Jefferysinspiration
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Jefferysinspiration
3,139 posts
Farmer

You've gave us no direction to go with this.
What is it that you want to discuss?

My view on the idea is that it could be very risky - even if it cures it, you don't want to end up with HIV, as sadly it can be just as tragic.

glaceonex23
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glaceonex23
424 posts
Nomad

Dude that's a lie. There's no way a HIV virus would do that. It might cause some catastrophic health disaster. And I do agree with Jeffery it could be very risky. Millions of people in Earth are in infected with HIV and then they want to add more infected with HIV?!?!

Jefferysinspiration
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Jefferysinspiration
3,139 posts
Farmer

If one was injected with HIV and had unprotected sexual intercourse - would they not pass it on? It could rapidly increase the number of HIV cases worldwide.

partydevil
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partydevil
5,129 posts
Jester

if they are able to remove the modified HIV cells from the body. then it looks like a very promising 1st step toward a real cure.

if i had cancer and i knew they are unable to remove/cure it by the normale way. then i surely volenteer to do this.
HIV is not aids yet. whit the proper medication HIV has no effect on the body anymore (unlike aids of wich you simply die)

so then the question is, die by cancer or daily medicate yourself against HIV. (easy answer for me)

MageGrayWolf
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MageGrayWolf
9,462 posts
Farmer

if they are able to remove the modified HIV cells from the body. then it looks like a very promising 1st step toward a real cure.


They don't really get into detail on how the virus was modified. It's quite possible they made it more controllable.
HahiHa
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HahiHa
8,256 posts
Regent

It is not well explained in the article, but for what I understood, they didn't inject the HIV's in the patients, they just used the viral mechanisms to inject the wanted DNA sequence in the patient's extracted T-cells, and put those T-cells back in the blood. If they did the transaction correctly, I guess there's almost no risk to being infected with HIV.

What I don't like is that they explain the case of three patients, but never say how much patients there were in total. Were there only those three? Were they the three most successful amongst thousands? To me, this isn't made clear in the article.

Also, this treatment can only work if you can synthetise a sequence that indeed does attack the wanted cells, here the cancer cells. There are different forms of cancer and not all react to the same treatment.

Somewhat49
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Somewhat49
1,606 posts
Nomad

Since the article is so unclear, I think the results weren't what they planned, but wanted to make the results look good, because, like Hahiha said, they never saw how many patients in total they tested, and if it was just those three, the experiment was too small for conclusive results.

Gstroy
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Gstroy
482 posts
Nomad

Did anyone actually read the article? They don't inject you with HIV, they take your blood out, add the HIV virus, which kills off most of the T-Cells, then they filter out the HIV virus and pump the blood back in, never do you have the HIV virus in your body, it's tested and safe. The thing is it only treats non tumor cancers, only blood related ones.

dair5
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dair5
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Shepherd

Did anyone actually read the article? They don't inject you with HIV, they take your blood out, add the HIV virus, which kills off most of the T-Cells, then they filter out the HIV virus and pump the blood back in, never do you have the HIV virus in your body, it's tested and safe. The thing is it only treats non tumor cancers, only blood related ones.


Actually they give modified HIV to your T-cells and insert them into your body.

2. A modified form of the HIV virus is used to infect the T-cells and insert genes that cause it to recognize and attack a particular cancer, then multiply and survive in the patients for months.


I almost like the idea. But what I don't like is that I'm not compleatly sure of the process. Do they take blood, infect and put back in all at the same time. Or do they they take T-cells, wait the next day. Then ifect them put them back in. I would perfer they do it all at once. What if the person was infected with a virus. His defenses are much lower now. A cancer patient with no T-cells is not the best match for a virus.

Also, can the HIV virus change and adapt so that it becomes AIDs, or that it becomes regular HIVs?
xNightwish
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xNightwish
1,608 posts
Nomad

I don't like idea. Because with this solution the HIV can infect other people I assume?
So you won't have cancer But you can give people HIV.

HahiHa
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HahiHa
8,256 posts
Regent

Did anyone actually read the article? They don't inject you with HIV, they take your blood out, add the HIV virus, which kills off most of the T-Cells, then they filter out the HIV virus and pump the blood back in, never do you have the HIV virus in your body, it's tested and safe.

So I understood it right. But to be honest, they never stated the filtering and the 'tested and safe' in the article. But it is made clear that the T-cells are taken out before being infected with the modified virus.

The thing is it only treats non tumor cancers, only blood related ones.

Ah, so it's not a cure for cancer, but fights and inhibit metastates, and probably is used in parallel with a more conventional method to fight the tumor cancer?

Actually they give modified HIV to your T-cells and insert them into your body.

As I said, I believe they simply used modified HIV's as a vessel/mechanism to inject only the wanted DNA sequence into the filtered T-cells, and put those back in the blood. Again, the article lacks details as to this procedure, but nowhere is it said that the whole HIV's genes are injected. I'm sure the procedure's quite safe. And so:
Also, can the HIV virus change and adapt so that it becomes AIDs, or that it becomes regular HIVs?

No because you won't be infected with HIV at all.

I don't like idea. Because with this solution the HIV can infect other people I assume?
So you won't have cancer But you can give people HIV.

As said, I'm sure they'll have modified the virus so that it injects not it's own sequence, but the wanted sequence into the T-cells, so theoretically there's no risks.
dair5
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dair5
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Shepherd

Well, I it's starting to make more sense to me now. Is it like they filter out T-cells, put the modified HIV in the soulution of T-cells and the HIV sticks to the cells and imputs DNA. Like that? What happens next, though. Do the cells just die off?

dair5
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dair5
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Shepherd

Sorry I meant does the virus just die off. Like gets eaten by the T-cells, unsticks and is somehow filtered out, ect...

MageGrayWolf
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MageGrayWolf
9,462 posts
Farmer

Here's a bit more on the research.

http://penncancer.org/penn_news.cfm?ID=1610

Something to note from this article.
"The Penn team pioneered the use of the HIV-derived vector in a clinical trial in 2003 in which they treated HIV patients with an antisense version of the virus. That trial demonstrated the safety of the lentiviral vector used in the present work."

If anyone wants to get a subscription this is where the research was published.
http://www.nejm.org/doi/full/10.1056/NEJMe1106965

Here's a video with some of the researchers talking about it.
http://bcove.me/b8knmsol

Gstroy
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Gstroy
482 posts
Nomad

Thanks Mage(or would you prefer it to be shortened to Gray or Wolf?).

Ah, so it's not a cure for cancer, but fights and inhibit metastates, and probably is used in parallel with a more conventional method to fight the tumor cancer?
My understanding is that cancer cells roam in your blood until they can find an area to infect, making a tumor. If the cancer cells are found early enough, they can get rid of it completely. And even if it isn't found in time, they can still kill the T-Cells in the blood and then use sound waves to break up the tumor, as they already do. So really, this is a really great idea, lets just hope it works in the end.
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