The gun that kills... Oh wait that is the person. The gun is just a hunk of metal. Probably a Colt .45 or a Smith and Wesson. I like handguns over rifles myself.
It really depends on the game. Some games have different tactics than others. For most games I choose an accurate automatic weapon with a fast rate of fire. I usually use dual mags, suppressor, grenade launcher and speed sling. I can wreak huge amounts of havoc with any automatic weapon and some grenades.
In any game, I would love to have the minigun by my side. It is a fast shooter, portable, looks awesome, and is easy to use. My favorite minigun is the laser minigun from Star Wars.
I enjoy using the .66c AG616 MOD. A bolt-action hammer rifle (that shoots hammers) crafted by Yours Truly, imbued with "mod powah", (that shoots hammers), which is useful for eliminating comments. It is so powerful, it deleted over twenty very-short comments in only 1.23 seconds.
In game I go for assault rifles and I would do the same in real life. I'd probably end up with an ak47 just because it is easy to make cheap and very reliable