So far, the only advice I can give is to make sure your paths are not narrow (at least 2 spaces wide). This way, the enemies have room to explode, preventing them from popping out of your pathway.
The red lines show weak points where splitters may break through. The corners are the most important to block off because those are the easiest places for splitters to pop through. As you can see, most of my path is 2 spaces wide, this way, splitters will bounce into the open area rather than out through the towers.
So, how exactly would you use this juggling in this game?
Make 2 symmetric paths and close one, then when they get to the end of the open one delete the other block and put in a block on the current path. Hotkeys help for this.
Delete the circled tower and place it where the other circle is when enemies get close to escaping.
When you start out, start with a wall like the towers with the black line through them. As you gain more bubbles, you can slowly expand your towers. When you are comfortable with the length of your trail, start upgrading towers.
I have a challenge for you guys: Build the most powerful Mega Mega Tower!
Some tips on MMT building: To get a range that covers the whole screen, all you need is a Sniper Tower. To get a reload of 1, all you need is a Machine Gun Tower and a Reload Booster Tower. To maximize damage, put a non-Booster tower in each of the four Mega Towers.